The lack of observed germline pathogenic DICER1 variation in TCGA thyroid carcinomas may be secondary to study tissue requirements, which mandated sufficient tumor size with at least 60% tumor nuclei (https://cancergenome.nih.gov/cancersselected/biospeccriteria); this may have biased the study to more severe or aggressive tumors. The gene discussed is DICER1; the disease is neoplasm.