TP53 and head and neck carcinoma: TP53 had the highest mutation frequency in the BQ‐TC cases and has also been reported to have a high mutation frequency in previous studies on head and neck carcinomas from the general population (Figure 4A and Table S11).34 However, the mutation frequency of TP53 in BQ‐TC (47%) is lower than that in TCGA‐TC (77%) (P = 0.0266, Fisher's exact test, two‐sided) (Figure 4B and Table S12).