It contributes to carcinogenesis by regulating the expression of large numbers of genes in tumour cells.25 In canonical Wnt‐signalling, β‐catenin is inhibited and accumulates in the cytoplasm, where it then it translocates to the nucleus to interact with transcription activators and drive the expression of Wnt target genes.22, 26, 27 This study also revealed that GATA5 interacts with β‐catenin in the cytoplasm, inhibiting β‐catenin from entering the nucleus. The gene discussed is GATA5; the disease is neoplasm.