Cleavage of EpCAM causes release of its intracellular domain into the nucleus, where it forms a complex with β‐catenin and other transcription factor to regulate the transcription of various genes, some of which cause malignant transformation of cancer cells.24 In our study, we performed immunohistochemical analysis and examined the expression of GATA5 and reprogramming genes in HCC tissue samples. Here, GATA5 is linked to cancer.