To further analyse whether GATA5 influences the expression of β‐catenin and reprogramming genes in HCC, we transfected HCC cells with a CDH‐GATA5 vectors, and Western blotting assays revealed that enhancing the expression of GATA5 reduced the expression of β‐catenin and reprogramming genes p‐Oct4, Nanog, Klf4, c‐myc and EpCAM (Figure 1C). Here, POU5F1 is linked to hepatocellular carcinoma.