GATA5 and hepatocellular carcinoma: The goal of the past decade had been to prospectively identify CSCs and to identify therapeutic strategies to safely eliminate this cell population.13 Recent findings reported that GATA5 suppresses HCC malignant transformation.5, 6 As such, the identification of the mechanisms whereby GATA5 inhibits cancer cell reprogramming of CSCs to suppress HCC malignant transformation is important.