The Wnt‐signalling pathway has emerged as a pivotal player in the reprogramming of cancer cells for invasion, migration and metastases in human cancer.28, 29 Reprogramming genes include p‐Oct4, Nanog, Klf4, c‐myc and EpCAM, which encourage stem cell replication that may be regulated by the Wnt‐signalling pathway.22, 30 However, the mechanism of reprogramming genes regulated by the Wnt‐signalling pathway in HCC remains unclear. This evidence concerns the gene KLF4 and cancer.