To further analyse whether GATA5 influences the expression of β‐catenin and reprogramming genes in HCC, we transfected HCC cells with a CDH‐GATA5 vectors, and Western blotting assays revealed that enhancing the expression of GATA5 reduced the expression of β‐catenin and reprogramming genes p‐Oct4, Nanog, Klf4, c‐myc and EpCAM (Figure 1C). The gene discussed is KLF4; the disease is hepatocellular carcinoma.