We next assessed the influence of GATA5 on expression of the invasion‐related factors MMP2 and MMP9.19 In the present study, the overexpression vector CHD‐GATA5 was transfected into HCC cells, and Western blotting results indicated that overexpression of GATA5 inhibited the expression of MMP2 and MMP9 in HCC cells (Figure 4A). The gene discussed is GATA5; the disease is hepatocellular carcinoma.