Any tumour that scored ≥42 or had a deleterious or suspected deleterious BRCA1/2 mutation was considered to have defective HR repair; tumours scoring <42 were considered to have functional HR repair.12 These markers reflect the degree of tumour genomic instability and are highly associated with defects in DNA repair pathway genes in ovarian cancers. The gene discussed is BRCA1; the disease is ovarian carcinoma.