ERBB2 and cancer: An ongoing, randomized, phase 2 study with an estimated enrollment of 140 patients will assess the effect of prophylactic octreotide, a somatostatin analog and established anti-diarrheal agent for cancer treatment-induced diarrhea, to prevent or reduce the frequency and severity of diarrhea in subjects receiving lapatinib in combination with capecitabine for the treatment of HER2 + metastatic breast cancer (Table 5) [62].