Just as it is true in the clinical course, the radiological progression over time is different for the different syndromes with accrual of new focal lesions in MS (both symptomatic and clinically silent lesions) and symptomatic lesions only at time of clinical relapses in patients with AQP4-Ab NMOSD and MOG-Ab-associated demyelination, with significant resolution of the lesions in follow-up scans. This evidence concerns the gene AQP4 and myeloid sarcoma.