However, the modern industrial western diet, characterized by an elevated omega-6/omega-3 ratio,16 leads to chronic overstimulation of CB1R.19,22,23 When combined with the elevated glycemic load of the modern western diet, this contributes strongly to increased rates of obesity, unfavorable lipid profiles, insulin resistance, exacerbation of inflammation in the liver and kidneys, and increased cardiometabolic risk.10,29,42,54,55. The gene discussed is CNR1; the disease is obesity due to melanocortin 4 receptor deficiency.