CNR1 and obesity due to melanocortin 4 receptor deficiency: The central role of CB1R in appetite, energy intake, energy conservation, and diet-induced obesity, and the hyperphagia and hypothermia resulting from acute stimulation of CB1R by THC, makes CB1R a prime suspect for a causative role in the effects of Cannabis use on BMI.22–24,27–32,41–46,74,75