Our results indicated that the single nucleotide polymorphisms (SNPs) interleukin-6 receptor (IL-6R) rs7529229 T/C [11] and hepatocyte nuclear factor 1 alpha (HNF1A) rs7310409 G/A [12] play essential roles in the inflammatory reaction and initiation process of CAD, thus contributing to the risk of LMCAD. The gene discussed is HNF1A; the disease is coronary artery disorder.