Likewise, IL-16 rs859 exerted a protective role in lung cancer development among males (recessive model: ref: A/A-G/A, adjusted OR = 0.62, 95% CI = 0.39-0.99, P = 0.045; log-additive model: adjusted OR = 0.73, 95% CI = 0.55-0.97, P =0.029) (Table 5). Here, IL16 is linked to lung cancer.