RNF213 and cerebrovascular disorder: In addition to point mutations, it has been found that four frameshift mutations in RNF213 are also associated with cerebrovascular disease, with c.1214_1216delGAG and c.11415delC associated with aneurysms [4] and c.1587_1589delCGC and c.12343_12345delAAA associated with MMD [17].