When TMZ was used as a covariate, HRs of GBM patients with high levels of RAN, KPNB1, or RAN/KPNB1 were 1.167, 1.397, or 2.108 with a P-value of 0.545, 0.235, or 0.186, respectively (Figure 5C and Table S1, panel RAN+TMZ, KPNB1+TMZ, and RAN/KPNB1+TMZ). Here, KPNB1 is linked to glioblastoma.