As shown in Figure 6A, importazole decreased the viability of the RAN-positive GBM cell lines A172, U87MG, U251, and SF-295 by >3-fold with a P < 0.0001, whereas the RAN-positive GBM cell lines LN-18, SF268, and T98G were much less sensitive to importazole (<3-fold) with a P < 0.001. Here, RAN is linked to glioblastoma.