By adding MGMT promoter methylation (MGMT) as an additional covariate, HRs of GBM patients with high levels of RAN or high levels of KPNB1 were 1.502 or 1.380 with a P-value of 0.178 or 0.322 (Figure 5C and Table S1, panel RAN+TMZ+MGMT and KPNB1+TMZ+MGMT). This evidence concerns the gene RAN and glioblastoma.