Secretion of Hsp90 b from tumor cells induces the phosphorylation of extracellular signal-regulated kinase by receptor low-density lipoprotein-related protein, and signaling by the complex of extracellular Hsp90, low-density lipoprotein-related protein 1, and extracellular signal-regulated kinase promotes cell motility and EMT by inducing matrix metalloproteinases and several EMT transcription factors, including Snail, Twist, Zeb, and Slug [305]. This evidence concerns the gene SNAI1 and neoplasm.