Interestingly, CD4+ T cells from RRMS patients expressed significantly higher levels of ERα compared with HD (Figure 4C), and this feature was peculiar of Th17 cells but not of Treg cells, as ERα was expressed at the same level both in Treg cells from HD and RRMS (Figure 4D). This evidence concerns the gene ESR1 and relapsing-remitting multiple sclerosis.