Also of relevance is a case report describing the presence of a TLR3 variant in a patient with recurrent HSV-2 meningitis (Mollaret's meningitis), thus adding another piece of data to the notion of an important role of the TLR3 signaling pathway for mounting protective IFN responses during HSV-1 and HSV2 neuroinfections (40). This evidence concerns the gene TLR3 and infectious meningitis.