Van de Veerdonk et al. analyzed 5 different families constituting 14 cases of AD CMC, leading to the finding of defective production of IFNβ, IL17, and IL22 in response to candida, and the identification of heterozygous mutations within conserved residues in exon 10 encoding the CC domain of STAT1 (98). Here, IFNB1 is linked to Alzheimer disease.