STAT3 and Alzheimer disease: Notably, HIES also exists in an AR form that may be caused by defects in either TYK2, dedicator of cytokinesis (DOCK)8, or phosphoglucomutase (PGN)3, although these present with a somewhat different phenotype, including a more pronounced tendency toward cutaneous viral infections and without the somatic phenotype characteristic of AD HIES resulting from STAT3 mutations (78, 93–95).