TNF and candidiasis: Interestingly, during systemic candidiasis there is an accumulation of neutrophils in all organs, except the brain (Lionakis et al., 2011) and these cells are able to produce a plethora of cytokines including, for example, TNF-α, IL-6, IL-10 and IL-5 (Tecchio et al., 2014; Xu et al., 2017) that were found elevated in spleen cell cultures from prednisolone treated mice, as described above.