Initial studies into use of general histone deacetylase (HDAC) inhibitors were unfavorable (178), however, subsequent use of selective HDAC inhibitors, such as chidamide, have shown anti-MM and bone protective effect, showing synergistic effects with other therapies such as dexamethasone, carfilzomib and pomalidomide (179). The gene discussed is HDAC9; the disease is Miyoshi myopathy.