GPC1 and pachyonychia congenita: In any event, in the future, further independent confirmation of exosomal GPC1 performance is needed, assessing its role as a more reliable marker in predicting diagnosis and prognosis of PC when compared to CA19-9, but also, and as it seems to be overexpressed in some precursor lesions such as IPMNs, its potential role in individualizing the management of such conditions (149).