SORT1 and renal carcinoma: By contrast, in peripheral cells or organs, the interaction of sortilin with p75NTR leads to renal cancer cell survival (De la Cruz-Morcillo et al., 2016) as well as B cell survival (Fauchais et al., 2008) whereas the complex between sortilin and TrkB is involved in colorectal cancer cell survival (Akil et al., 2011).