HIF1A and hepatocellular carcinoma: For instance, some Chinese medicine, such as the Yiqi Huayu Jiedu prescription, has been used as regular treatment for patients with hepatocellular carcinoma after radiotherapy and chemotherapy, which has been demonstrated to inhibit tumor angiogenesis by downregulating HIF-1α, Twist1, Bcl-2, MMP-2, MMP-9 and upregulating E-cad (Zeng et al., 2015).