CHB-II-F may be down-regulating the expression of Bcl-2 and up-regulating the expression of Bax, while activating both caspase-3 and caspase-9, fixing tumor cells in G0-G1 transition, increasing the rate of apoptosis of rumor cells and stimulating cells to initiate the process of apoptosis. The gene discussed is BCL2; the disease is neoplasm.