AKT1 and neoplasm: GSK-3β, a serine/threonine kinase (Doble and Woodgett, 2003), is abnormally enriched in human PC cells and another downstream effector of AKT and can be phosphorylated and deactivated by AKT, its aggregation in the nucleus is related to tumor differentiation and kinase activity (Ougolkov et al., 2006; Zhang et al., 2015).