Previous studies have confirmed that Akt/GSK-3β modulates the metastasis of different type of tumors by regulating EMT, such as gastric, lung, hepatocellular, breast carcinoma, head and neck squamous cell carcinoma and colorectal, prostate, bladder cancer (Zhang et al., 2013; Liu et al., 2014; Zhou et al., 2015). The gene discussed is GSK3B; the disease is head and neck squamous cell carcinoma.