AKT1 and neoplasm: The Akt signaling pathway is one of the main survival pathways in tumor cells, and its expression rate is frequently high in many cases of carcinoma, multiple pathological processes are involved with the dysregulation of this pathway, including proliferation, cell cycle, migration, invasion, angiogenesis, metastasis, tumorigenesis, and drug resistance (Chan et al., 2014; Zhang et al., 2015).