Cardiac hypertrophy is characterized by an increase in cell size and protein synthesis, an enhancement of sarcomeric organization, and reactivation of fetal genes, including atrial natriuretic peptide (ANF) and brain natriuretic peptide (BNP), and β-myosin heavy chain (β-MHC) (Cotecchia et al., 2015). Here, NPPB is linked to cardiac hypertrophy.