The decrease in deacetylase activity of SIRT6 might contribute to the development of cardiac hypertrophy (Cai et al., 2012; Sundaresan et al., 2012; Yu et al., 2013; Lu et al., 2016; Shen et al., 2016; Zhang et al., 2016). The gene discussed is SIRT6; the disease is cardiac hypertrophy.