NFATc4, a member of nuclear factor of activated T cells (NFAT) transcription factor family, has been well-documented for its involvement in several diseases including cardiac hypertrophy, by regulating various target genes (Horsley and Pavlath, 2002; Li et al., 2016a, 2017; Zhang and Storey, 2016; Wang et al., 2017; Sharma et al., 2018). This evidence concerns the gene NFATC4 and cardiac hypertrophy.