SIRT6 and cardiovascular disorder: As a promising therapeutic target for cardiovascular diseases (Vitiello et al., 2017), SIRT6 demonstrates potent anti-hypertrophic effect both in vivo and in vitro (Cai et al., 2012; Sundaresan et al., 2012; Yu et al., 2013; Lu et al., 2016; Shen et al., 2016; Zhang et al., 2016).