Furthermore, recent advances indicated that activation of the Nrf2 pathway was protective in alcohol-induced liver fibrosis and hepatotoxicity, whereas knockdown of Nrf2 was associated with enhanced alcohol-induced hepatocyte necroptosis (Song et al., 2015; Lu et al., 2016; Ni et al., 2017). This evidence concerns the gene NFE2L2 and Hepatic fibrosis.