NFE2L2 and hepatocellular carcinoma: Thus, advances were made to regulate the Nrf2 pathway in HCC, including identification of miR-340, miR-144, camptothecin, and valproic acid, which were revealed to be effective in suppressing the Nrf2-dependent pathway, thereby sensitizing HCC cells to anticancer treatments (Shi et al., 2014; Zhou et al., 2016; Chen et al., 2017; Yu et al., 2017) (Figure 5).