On the contrary, activation of the EGFR pathway can accelerate renal recovery in the early AKI phase by means of a mechanism that involves induction of renal tubular cell regeneration and protection of these cells from apoptosis, as demonstrated by the in vivo administration of several ligands (EGF, HBEGF) in experimental acute ischemic injury [69, 73–78]. This evidence concerns the gene EGFR and acute kidney injury.