In experimental models of hypertension induced by several factors (Ang II, leptin, monocrotaline, or ET1), EGFR blockade by different approaches including antisense oligonucleotides for EGFR, inhibitors of the EGFR kinase, and mutated WAVED-2 mice reduced the characteristic effects of tissue damage observed in these models [250–253]. The gene discussed is EGFR; the disease is Hypertension.