ERBB4 and colorectal neoplasm: In various types of cancer, including tumors of the head, neck, lung, and breast and colorectal tumors, the ErbB family of receptors (EGFR/HER1/ERBB1, HER2/neu/ERBB2, HER3/ERBB3, and HER4/ERBB4) is unregulated, producing an inappropriate cell stimulation [254, 256].