In our in vivo experiment, the transfer of purified CD11b+Ly6Chi pristane-induced peritoneal monocytes was able to greatly inhibit anti-keyhole limpet hemocyanin (KLH) antibody production induced by KLH immunization [53], suggesting that these cells may have a protective effect in chronic autoimmune inflammation in pristane-induced lupus. This evidence concerns the gene ITGAM and systemic lupus erythematosus.