Although E-/N-cadherin interaction has been reported in the adhesion of A431 epidermoid carcinoma cells to CAFs21, a function-blocking antibody against E-cadherin, which completely blocked the homotypic cell-cell adhesion of MCF-7 cells (Fig. S5c), did not inhibit the adhesion of Panc-1 cells to fibroblasts at all (Figs 4b and S5b). This evidence concerns the gene CDH1 and squamous cell carcinoma.