FN1 and cancer: Moreover, poor interaction between cancer cells and fibroblasts in the 3D collagen matrix was observed when the Panc-1/WI-38 chimeric spheroids without siRNA treatment were treated with the anti-integrin-α5β1 or the anti-fibronectin antibody (p < 0.05 and p = 0.066, respectively) (Fig. 6d,e).