For example, fibroblast-derived HGF facilitates the growth and invasive activity of cancer cells10, while TGF-β induces the epithelial to mesenchymal transition (EMT) of cancer cells, a key step to the invasive cancer cells11 and converts normal fibroblasts to the activated fibroblasts, i.e. myofibroblasts or CAFs12. Here, TGFB1 is linked to cancer.