The mitochondrial DNA copy number was significantly decreased in raptor silenced cells as compared to control (P < 0001, n = 6/each group; Fig. 5d), whereas mTORC2 inhibition (rictor silencing) did not affect the mitochondrial biogenesis in PHT cells (Fig. 5e). The gene discussed is RICTOR; the disease is pulmonary hypertension, primary, 1.