The expression levels of several favorable neuroblastoma genes were found to be significantly altered in Th-MYCN/Casp2−/− tumors, including increased expression of Slc18A1, Vip, and reduced expression of Gata2, Gch1, Fgr, and Six6. While the decrease in tyrosine hydroxylase (Th) expression was not significant in the biological replicates (FDR =0.584) (Fig. 5a, Supplementary Table S7a), we did note that several genes adjacent to Th on chromosome 7 (Ascl2, Igf2, and H19) were also somewhat decreased (Supplementary Table S7b). Here, IGF2 is linked to neuroblastoma.