MYCN and neoplasm: To identify the transcriptomic differences in tumors from Casp2−/− mice that are associated with delayed Th-MYCN induced neuroblastoma30 and/or enhanced EμMyc lymphoma development7, we carried out RNA sequencing on tumor tissue isolated from Th-MYCN and Th-MYCN/Casp2−/− or from EμMyc and EμMyc/Casp2−/− mice (Fig. 1a, Supplementary Tables S1a-b).