SLC6A4 and Anxiety: Here we first confirmed that that there was reduced transcription of SERT mRNA and protein expression within the DRn and MRN of SERT+/− rats and at the limit of detection in SERT−/− rats, then also confirmed that SERT−/− rats, but not SERT+/− rats, had high baseline anxiety associated behaviors, which are both consistent with previous reports42–44.