In our studies with patient samples from Guangxi, one of the regions with the highest incidence of HCC in China, we found that RBM8A was overexpressed in HCC tumor tissues compared to normal liver tissues, and this overexpression was associated with the surface antigen of the hepatitis B virus (HBsAg) and Edmondson pathological grading. This evidence concerns the gene RBM8A and neoplasm.