NFKB1 and malignant colon neoplasm: It is reported that human colon cancer cells HCT116 can be induced to senescence by low concentration of Doxorubicin treatment, and possess typical senescent cell features such as the persistent DDR, the up-regulation of NF-κB activity and SASP expression which is similar to replicative senescence and other stimuli-induced premature senescence [22].