APC and retinal degeneration: Interestingly, RNAi-mediated knockdown of fatty acid synthase 1 (Fasn1) but not of Apc or Vha55 partially rescued the ERG defects of miR-210Δ mutant flies (n = 5-7; *P < 0.05) (Fig 5D), suggesting that up-regulation of Fasn1 activity might contribute to the retinal degeneration observed in miR-210Δ mutants.