As summarized in Table 2, several statistically significant relationships were identified between covariates and IIV for PK parameters: BW and infection type on CL; BSA and infection type on Vc; infection type on CLd1; BSA, age, and infection type on Vp1; height and infection type on CLd2; and BW and vasopressor use on Vp2. The gene discussed is CLDN1; the disease is infection.