Aβ42-mediated cell death in the brains of both AD patients and animal AD models has been linked to various molecular signals including activation of mitogen-activated protein kinases (MAPKs) such as p38, extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK), as well as suppression of phosphoinositide 3-kinase (PI3K)/AKT and glycogen synthase kinase-3 (GSK-3) (Zhu et al., 2001; Pearson et al., 2006; Ma et al., 2007; Young et al., 2009; Sofola et al., 2010; Tare et al., 2011; Yin et al., 2011; Povellato et al., 2013). The gene discussed is WNK2; the disease is Alzheimer disease.