CD226 and lung cancer: To further explore the potential of DNTs for use as effector cells against lung cancer, we screened DNTs for their expression of molecules known to be involved in immune cell mediated anti-tumor responses [19], including NKG2D, DNAM-1, the family of natural cytotoxicity receptors (NCR) NKp30, NKp44 and NKp46, FasL, membrane TRAIL (mTRAIL), perforin and granzyme B. Expanded DNTs showed a > 150-fold increase in MFI values for NKG2D and DNAM-1, and a 2-fold increase in NKp30, FasL, and mTRAIL expression compared to isotype controls (Fig. 2a and b).