Indeed, the cytotoxicity-mediated by IL-15 stimulated DNTs was significantly reduced to the levels of unstimulated DNTs (Fig. 4a) when NKG2D, DNAM-1 and NKp30 was blocked (Fig. 7c), suggesting a similar mechanism of recognition against NSCLC cell lines by IL-15-stimulated and non-stimulated DNTs. The gene discussed is CD226; the disease is non-small cell lung carcinoma.