Quantitative real-time PCR revealed that BMP2, DKK1, FGF5, IGF2, MET, PNP, SEMA3A, SPRY2, WNK4, and TJP2 were statistically downregulated in human Sertoli cells of SCOS patients compared to OA patients (Fig. 3a). The gene discussed is TJP2; the disease is small cell osteogenic sarcoma.