ERBB2 and breast carcinoma: To more fully understand the consequences of the HER2-mediated hypoxic response, genes shown to be upregulated by hypoxia specifically in HER2-positive cells (‘HER2-specific’) and hypoxia-responsive genes shown to be more highly expressed in MCF7-HER2 than in wild-type MCF7 in normoxia (‘HER2-primed’) were assessed for known roles in breast cancer (Fig. 5b).