Genes involved included a large number of known glycolytic genes (ALDOA, PDK1, PFKFB3, PFKP, ENO1, PGK1, GPI, HK2 and PGAM1) as well as a number of non-glycolytic drivers of cancer progression (CAIX, VEGFA, LOX and ANGPTL4). This evidence concerns the gene PFKFB3 and cancer.