For example, in the TgCRND8 model (APP KM670/671NL + V717F), we demonstrate similar patterns of upregulated RyR-evoked Ca2+ release and spike-evoked Ca2+ responses in hippocampal neurons as the 3xTg-AD mouse, and a marked suppression of PTP and E-LTP in the PS1/APP (APPSWE/PS1M146V) models (Additional file 1: Figure S1). This evidence concerns the gene PSEN1 and Alzheimer disease.