APP and Alzheimer disease: The pathogenic ER Ca2+ dyshomeostasis component of AD has been consistently demonstrated over many years across numerous AD mouse models including the PS1M146VKI [17, 111], PS1/APP (APPSWE/PS1M146V) [112], PS1/APP (C57BL/6-SJLF1-APP+/−/C57BL/6-D2F1-PS1+/−; 113) and Tg2576 [114] among others [15, 22].