Administration of 1 μg/g[body weight] LPS to 10 weeks old C57BL/6 J (B6) mice was sufficient to drive the entry of CD45hi/CD11b+/CD11c+ infiltrating monocyte-like cells into the ONH over a 21-day period at a similar number (100–300 cells) to that which occurs in D2 glaucoma [18] (Fig. 4a and b) (without causing optic nerve degeneration as assessed by PPD staining, data not shown). This evidence concerns the gene ITGAX and glaucoma.