ITGAM and iris disorder: D2.Itgam−/− mice had no detectable levels of CD11b protein, and had iris disease that was indistinguishable from wild-type controls and ocular hypertension that was indistinguishable from wild-type controls at 8 and 10 months of age but tended to persist longer (P < 0.01 at 12 months of age) (Additional file 17: Figure S11).