Module 1 was characterized by metabolic pathways especially mitochondrial dysfunction and mTOR signalling, both implicated in glaucoma [33, 53–55], Module 2 by inflammatory pathways (IL10, IL6, PI3K in macrophages), Module 3 by RNA/DNA events related to both splicing and repair, Module 4 by metabolic pathways (glycogen, cholesterol, mitochondrial dysfunction), and Module 5 by repair pathways (ATM signalling) and platelet aggregation (thrombin signalling) (Additional file 9: Figure S6, Additional file 10: Table S4). This evidence concerns the gene ATM and glaucoma.