FUT4 and malignant colon neoplasm: In this context, studies have shown that CD15, also called Lewisx antigen, synthetized by Fucosyltransferase 4 (FUT4), is induced by the RAF-MEK-ERK signaling pathway, and colon cancers that are FUT4+/CD15+ seem to exhibit significant alteration of the systemic immune surveillance and resistance to the anti-EGFR agents (cetuximab) [5].