Notably, two genes of cluster i) a member of the lymphocyte antigen-6 (Ly6) complex, locus G6D (LY6G6D), localized on the MHC class III region (6p21) and ii) a member of the fucosyltransferase genes (FUT4), encoding for the fucosylated Lewisx antigen, here called CD15, as reported [5], were highly overexpressed in CRC, discriminating MSI and MSS subtypes (Fig. 1a, Additional file 3: Figure S1a). This evidence concerns the gene FUT4 and colorectal carcinoma.