Indeed, we found that the treatment with momelotinib or trametinib and its combination (JAKi/MEKi) resulted in a dramatic suppression of the growth rate of CRC cells known to have a primary resistance to Mab cetuximab (anti-EGFR) [24] (Additional file 3: Figure S5c and d). This evidence concerns the gene EGFR and colorectal carcinoma.