For example, activation of UPR pathways by Dengue virus (DENV) was found to be dependent on the time of infection: early PERK activation and eIF2α phosphorylation were triggered in the early stage of DENV infection; during mid and late stages, the PERK pathway was switched off and the IRE1 and ATF6 pathways activated, respectively [3]. The gene discussed is ATF6; the disease is infection.