Studies have shown that t-PA is highly enriched in all kinds of types of neurons in the human central nervous system (CNS), including neocortex, pyramidal neurons, and hippocampus, and thus is involved in several physiological and pathological processes in the CNS, such as learning and memory, anxiety, epilepsy, stroke, Alzheimer’s disease, and spinal cord injuries [13, 14]. Here, PLAT is linked to epilepsy.