Although previous data showed that these SNPs were not only associated with multiple thrombotic disorders, such as strokes [20, 22, 28], myocardial infarction [29–31], but also with the severity of bacterial infections, such as meningitis [32, 33], it remains blank concerning the relationship between t-PA, PAI-1 polymorphisms and TLE. The gene discussed is SERPINE1; the disease is thrombotic disease.