Furthermore, immunohistochemical studies revealed an increased expression of P-selectin on the endothelium covering human atherosclerotic lesions [16], on the endothelium of patients with unstable angina [17] and in the vasculature of tumours, including lung, ovarian, lymphoma and breast tumours [18], proposing P-selectin as a suitable target for imaging and therapeutic intervention in humans. The gene discussed is SELP; the disease is angina unstable.