Using a chemical model to mimic AD related neuropathological features by okadaic acid injection into the lateral ventricles [65] only transplantation of rat NSCs (both derived from the SVZ or SGZ of embryonic rats) overexpressing human nerve growth factor (NGF-NSCs) led to robust survival, migration, and integration while non-overexpressing NSCs did not. This evidence concerns the gene NGF and Alzheimer disease.