In a murine AD model (APP/PS1 mice), neuron-specific Thy1 promotor driving the co-expression of KM670/671NL mutated amyloid precursor protein (APP) and of L166P mutated presenilin-1 (PS1) leads to human amyloid depositions and local neuronal loss in the dentate gyrus [49,50]. The gene discussed is PSEN1; the disease is Alzheimer disease.