SMC3 and acute myeloid leukemia: A similar approach was used by another group to edit commonly mutated AML genes such as TET2, ASXL1, DNMT3A, RUNX1, TP53, NF1, STAG2 and SMC3 in human umbilical cord blood (UCB) and adult CD34+ cells, by introducing a pool of 11-targeted sgRNAs [157].