RUNX1 and acute lymphoblastic leukemia: Experimental irradiation was also shown to accelerate the development of leukaemia in engineered mouse models, for example, such as the acute lymphoblastic leukaemia (ALL) associated with t(12;21)(p13;q22) leading to a TEL-AML1 (aka ETV6-RUNX1) fusion, coupled with a loss of the CDKN2A cell cycle regulator gene [33].