Transduction of enriched hematopoietic stem and distinct progenitor cells showed that in contrast to BCR-ABL, AML-associated MOZ-TIF2 [114], MLL-AF9 [115,116], MLL-ENL [117,118], AML1-ETO [119] and MLL-GAS7 [120] fusion genes were able to transform committed progenitor cells. The gene discussed is RUNX1; the disease is acute myeloid leukemia.