RUNX1T1 and leukemia: A RUNX1-ETO leukaemia model that allows for conditional and reversible controlled mosaic expression of the fusion in hematopoietic progenitors was established by transplanting whole BM carrying a ROSA26-iM2-tetO DOX inducible promoter and the fusion cDNA (ROSA26-iM2-tetOGFP/TgPtet-AML1-ETO) into lethally irradiated mice [82].