The induction of cytokines (IL6 and TNFα), chemokines (CCL2 and CXCL10), and IFN-I genes in primary C57BL/6 astrocytes following a TMEV-BeAn infection can be mediated by TLR3 but not TLR7 or other MyD88-mediated pathways [159]. The gene discussed is TNF; the disease is infection.