CD8A and infection: Referring to this, using magnetic resonance imaging, virus-specific cytotoxic CD8+ T cells have been shown to induce T1 hypointensive lesions (“T1 black holes”) in mouse brains following a TMEV-DA infection, as demonstrated by adoptive transfer experiments in RAG-1-deficient mice and epitope-specific CD8+ T cell depletion experiments in C57BL/6 mice [223].