CD8A and demyelinating disease: Moreover, the antibody-mediated depletion of CD8+ T cells prior to a TMEV infection has been shown to diminish viral clearance causing an increased severity of demyelinating diseases in susceptible SJL mice (TMEV-BeAn) and the presence of small demyelinating lesions in resistant C57BL/10 mice (TMEV-DA), respectively [227,228].