BHLHE40 and cancer: We saw increased mRNA expression of ADM (adrenomedullin), ANGPTL4 (angiopoietin-like 4), BHLHE40 (Class E basic helix-loop-helix protein 40, also known as Dec1), BNIP3 (BCL2/adenovirus E1B 19 kDa protein-interacting protein 3), CA9 (carbonic anhydrase IX), CXCL8 (interleukin 8) and DDIT4 (DNA-damage-inducible transcript 4), all genes with confirmed HRE binding sites in their promoters [23] and roles in cancer progression (Figure 3C).