In a series of adult T-ALL patients, the presence of SET-NUP214 correlated with upregulation of HOX genes and with high expression levels of the lymphoblastic leukemia associated hematopoiesis regulator 1(LYL1) and the myocyte enhancer factor 2C (MEF2C) genes [95]. Here, LYL1 is linked to acute lymphoblastic leukemia.