RAC1 and non-small cell lung carcinoma: In endothelial cells and non-small-cell lung cancers (NSCLCs), GIT1 functions with PIX (PAK-interacting exchange factor), an exchange factor for Rac1 and Cdc42, to positively regulate Rac1 and Cdc42 activity, and cortactin, an F-actin binding and bundling protein, to promote membrane protrusions and cell migration [56,99].