Five Arf GAPs have been shown to associate with podosomes or invadopodia: ASAP1 with podosomes induced by active Src in fibroblasts and invadopodia in cancer cells [29]; ARAP1, GIT1 and GIT2 with podosome belts in osteoclasts [41,63]; and ARAP3 with podosome-like structures in fibroblasts plated on a fluid substrate [50]. This evidence concerns the gene SRC and cancer.