Meanwhile, fecal immunochemical tests (FITs) for hemoglobin (Hb) are widely recommended and used for CRC screening in many countries [5,6,7,8,9], as they have been shown to yield substantially better diagnostic performance [10,11,12] and significantly higher participation rates [13,14] in direct comparisons with gFOBTs. This evidence concerns the gene GSTM1 and colorectal carcinoma.