The LuCaP PDX models show the major genomic and phenotypic features of PCa specimens obtained from patients, including AR amplification, PTEN deletion, TP53 deletion and mutation, RB1 loss, TMPRSS-ERG rearrangement, SPOP mutation, hypermutation due to MSH2/MSH6 genomic aberrations, and BRCA2 loss. This evidence concerns the gene AR and posterior cortical atrophy.